| ncRNA name | Sirna-027 |
| ncRNA Category | siRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Homo sapiens |
| Tissues/Cell_line | human aortic endothelial cells (HAECs), HeLa S3 cells |
| Methods | BrdU labeling, siRNA transfection, qRT-PCR, luciferase reporter assay, ELISA |
| Expression pattern | associated |
| Functional description | We used siRNA directed against vegfr1 mRNA to investigate the role of VEGFR1 in ocular neovascularization. After evaluating many siRNAs, Sirna-027 was identified. In a CNV model, intravitreous or periocular injections of Sirna-027 resulted in significant reductions in the area of NV. In mice with ischemic retinopathy, intravitreous injection of Sirna-027 reduced retinal NV by 32%. |
| PubMed ID | 16195704 |
| Year | 2006 |
| Title | Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1. |
| Drug-related ncRNA | NO |
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